Tadalafil is an oral drug for the treatment of ED. It is used for the treatment of erectile dysfunction and premature ejaculation, which has a very significant improvement. More than 1500 documents have proved the causes of impotence and premature ejaculation caused by different reasons. It is known that its success rate is more than 80% and has shown its reliable curative effect. Through more than 20 million people worldwide, it has proved its long-term stability. , The functional safety of 25 to 60 minutes is consistent with the time required for foreplay. Knowing that time adjustments are made during the maximum drug concentration time will help the couple to obtain a satisfactory sex life.
Tadalafil is a PDE-5 inhibitor. When the body is sexually stimulated to cause local release of nitric oxide, tadalafil can inhibit PDE-5; at this time, the level of cyclic guanosine phosphate in the penile cavernous body increases , Vascular smooth muscle relaxes, blood can flow into the penis smoothly, making the penis produce an erection; and when there is no sexual stimulation, tadalafil does not work.
Tadalafil is also a selective inhibitor of PDE5. PDE5 is an enzyme found in the smooth muscle of the corpus cavernosum, smooth muscle of blood vessels and internal organs, skeletal muscle, platelets, kidneys, lungs and cerebellum. Tadalafil has a stronger effect on PDE5 than other phosphodiesterase enzymes. The effect of tadalafil on PDE5 is more than 10,000 times stronger than the effect on PDE1, PDE2, PDE4 found in the heart, brain, blood vessels, liver and other organs. The effect of tadalafil on PDE5 is more than 10,000 times stronger than the effect on PDE3 found in the heart and blood vessels. The selectivity of PDE5 over PDE3 is very important because PDE3 is related to myocardial contractility. In addition, the effect of tadalafil on PDE5 is about 700 times stronger than that on PDE6, which is present in the retina and participates in light transmission. The effect of tadalafil on PDE5 is more than 10,000 times stronger than on PDE7-10.
Post time: Oct-10-2020